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One could impose additional constraints on the design process, such as to ensure that every key has an acceptable error rate in addition to an acceptable average error rate.
Thirdly, the targeted therapeutic that is developed needs to specifically and selectively inhibit the target, and as such needs to have a significant anti-cancer effect on the cell (whether it be to inhibit cell proliferation, to induce apoptosis or to enhance sensitivity to other concomitant therapies), in addition to an acceptable toxicity profile.
These results, in addition to an acceptable toxicity profile for the combination therapy, led to the expansion of the study into the ABC-02 trial, a randomised phase III study of 410 patients with advanced biliary tract cancers that demonstrated a median overall survival (OS) of 11.2 vs 7.7 months in favour of the gemcitabine plus cisplatin compared with gemcitabine monotherapy (P<0.001).
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In addition to an entire chapter (ch.
Of these, 1644 (70%) were selected for an ELISPOT test in addition to a tuberculin test and had acceptable results for both (Figure 1).
Thus, it would seem reasonable to propose that the de novo prescription of the extended-release formulation to KTRs may be considered as an acceptable option for immunosuppressive therapy, in addition to a strategy of conversion from the standard-release to extended-release formulation at varying times post-transplant that has been shown in other studies [ 4– 6].
The results show that in addition to ensuring an acceptable level of privacy, the released datasets from the privacy-enhancing system can also be applied to urban traffic modeling with satisfactory results.
Thus, vitamin E measurements, may, in addition to being an acceptable index of lipid peroxidation, be important as the ultimate defense barrier against IR insult [ 13].
In addition to demonstrating acceptable content validity in patients with CRPC, a review of evidence in relation to the BPI-SF 'Worst Pain' item also suggests that this item fulfils much of the key criteria specified in the recent FDA PRO Guidance for Industry [ 24, 44].
In addition to maintaining acceptable voltage at all points along the distribution feeder, the aim is to determine the proper settings of shunt capacitors and transformer load tap changers in order to minimize the energy loss or the energy consumption over a selected planning horizon.
Reconstructive surgery is not simply filling a defect, but it encompasses a wide knowledge of tissue handling, perfusion and healing, in addition to achieving acceptable aesthetic results.
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