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One of the major challenges in developing AO-based therapeutics is to achieve efficient delivery to disease-relevant tissue in vivo and, in addition, overcome the cellular barriers that prevent AOs from reaching intracellular molecular targets in the nucleus where splicing takes place.
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In addition, overcoming its activity in resistant cancer cells has not been achieved in the clinic, thereby garnering some degree of pessimism in the field.
In addition, to overcome the increase in the circuit area occupation caused by the additional matching resonator in a cascaded structure, small 3-D inductors are adopted in our design.
In addition, to overcome the difficulties in solving the objectives of all the scenarios, scenario bundling and sensitivity analysis algorithms are developed to improve the computational efficiency.
In addition, to overcome the worldwide problem of antibiotic overuse as well as misuse, biomarker guidance of antibiotic stewardship represents a promising new approach.
In addition, to overcome the approximation and bandwidth problems of ACO routing algorithms, Khosrowshahi et al. [23] proposed a novel protocol where the node is switched between local and global zone while taking routing decisions.
In addition, to overcome the inherent mechanical weakness of the porous low k material, extensive finite element modeling is used to design and define mechanically stronger structures for better die saw immunity and package robustness of various packaging requirements [T.C.
In addition, they overcome some of the limitations observed in a recent report by Grimm et al. [37].
In addition, to overcome the problem of haplotype phasing in the possible presence of some recombinations, we estimated effect sizes such as relative risks with conditional logistic regression under a log-additive mode of inheritance applying the R-package 'DGCgenetics' provided by David Clayton.
In addition, liposomes overcome problems inherent with viral vectors – specific concerns over immunogenicity and replication competent virus contamination.
In addition, to overcome the problematic drug drug interactions, the doses of these drugs had to be decreased, which attenuated their efficacy.
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