We show that SPINK1 not only affects invasion, motility and cellular survival as reported previously, but, in addition, confers chemoresistance to multiple drugs by decreasing caspase-3 levels and increasing basal levels of anti-apoptotic factors, Bcl2 and phosphor-Bcl2.
For instance, studies have suggested that bistability is a key system feature for apoptotic signaling networks [ 15, 16, 21- 23], which could achieve the all-or-none responses and in addition confer robustness to the apoptosis system [ 18, 24, 25].
Peptide addition conferred no cytotoxicity in vitro, and similar therapeutic effects against tuberculosis were seen with four times less DNA compared with naked DNA treatment.
In addition, it conferred sensitivity to autocrine FGF18-mediated growth and migration signals in SW480 cells with low endogenous FGFR3-IIIc expression.
In addition, cytoprotection conferred by PRO-Pep4p was autophagy-independent to the same extent as shown for WT-Pep4p (Supplementary Figures S4E G).
In addition, BHE conferred protection against liver damage as evidenced by the marked decrease in lymphocyte infiltration, hydropic degeneration, fatty changes, central vein congestion, Kupffer cell hyperplasia, and necrotic changes.
In addition to conferring Herceptin resistance, t-Darpp is also reported to confer resistance to drug-induced apoptosis, apparently via a mechanism that involves CREB activation [32].
In addition to conferring resistance or decreased susceptibility to extended-spectrum cephalosporins such as ceftiofur and ceftriaxone, this gene also confers resistance to ampicillin (AMP), amoxillin-clavulanate, cephalothin, and cefoxitin.
In addition to conferring more rights on gay couples, the changes might also require more responsibilities.
Speer, Lee, and Johnson would return to these tapes sporadically when they gathered in a barn in Burton, Texas (in addition to conferring via Skype when Lee briefly relocated to London), to write and record "Universe".
