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The actin cytoskeleton is both an upstream regulator of MRTF activity, with monomeric (G) actin directly acting as a signal transducer, and a downstream effector of SRF resulting in activation of cluster genes encoding components of the actin cytoskeleton [8], [9], [10].
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The delay in activation of the small clusters was negligible (<2 ms) for distances ≤150 nm.
Several genes including SDC2 as a methylation cluster are involved in activation of TGF-beta pathway in ovarian cancer [ 46].
For the sequential tapping and card flipping tasks, by using CCA to group source-detector pairs with similar temporal patterns (Section 2.6) into a single cluster, the difference in activation duration of the cluster containing the PMC/SMA and S1/PPC regions versus duration of the M1 cluster can be shown to be statistically significant (Section 3.2.2).
In the G2/M phase, Fkh1 and Fkh2 play essential roles in the activation of the CLB2 cluster genes and they share 72% identical DNA binding domain.
In order to further understand the mechanisms involved in the activation of the miRNA clusters one cell line of the 19q13 group has been investigated in more detail.
Surface induced electronic charge on the deposited cluster results in red shift in its energy levels, indicating electron rich activation of platinum clusters.
From the actual evidence, it is safe to presume that histone H3 acetylation in promoter regions of SM cluster genes by GcnE-containing complexes is essential for transcriptional activation of SM clusters in A. nidulans.
In addition, histone H4 acetylation has been shown to convoy transcriptional activation of several clusters in A. nidulans and A. parasiticus and thus seems to play a role during the activation process.
In support of such a mechanism Linz and colleagues recently found that the oxidative stress pathway mediated by cAMP-response elements is involved in the activation of the aflatoxin gene cluster in A. parasiticus (Roze et al. 2011).
We call this process "the guanine-proximity-induced activation of silver clusters" or, in short, "the activation of NCBs".
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