The two patients described in our first paper actually confirmed the general rule for the therapy with Tregs in humans it is effective in the treatment of chronic GvHD and ineffective in accelerated forms (grade IV) of acute GvHD [ 66].
Support for this hypothesis originates from experiments on TNF-alpha homozygous knockout mice in which intratracheal administration of bleomycin resulted in an accelerated form of pulmonary fibrosis.
20 The nature of our sample did not permit an exhaustive examination of TBI-related age-relatedated cognitive dysfunction; however, our interpretation of results supports the idea that the pattern of brain changes detected in TBI patients has similar functional consequences to normal ageing, albeit occurring in an accelerated form.
When some cancers metastasize and punch holes in the bone to support their survival, they imitate an accelerated form of osteoporosis — in effect, recapitulating the aging process in bone.
In other words, it's an accelerated form of selective breeding – and some in the field hope it will be a game changer.
In DC, osteoporosis is an accelerated form of that seen with physiological aging, whereas the osteoporosis of WS affects the limbs as well as the axial skeleton (Hofer et al., 2005; Mason et al., 2005).
Macroangiopathy in diabetes consists mainly of an accelerated form of atherosclerosis and affects all clinically important sites, i.e. the coronary, the carotid and the peripheral arteries, thus increasing the risk of myocardial infarction, stroke and peripheral artery disease.
11 14 Recently, an accelerated form of EBCD was tested in intensive care and lung cancer services in the UK.
In the years following that multiple seizure, Clinton went for the accelerated form adopted by Nixon.
