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Thus, despite the reduction in ACC between 2010 and 2012, earthworm ACC appears to be stable for several years.
We propose FABP7 as a novel biomarker in ACC.
Chidamide alone or in combination with cDDP did not induce distinct apoptosis in ACC cells.
It demonstrated anticancer effects in various cancers in preclinical study, but not in ACC.
Significantly reduced Fhit and Wwox expression was observed in ACC (p = 0.002 and p < 0.001, respectively).
There was a linear increase in SMA and a linear decrease with age in ACC activity.
Fig. 1 High PLK1 mRNA expression is associated with worse prognosis in ACC tumors.
Recent studies have suggested that the transmembrane tyrosine kinase receptor, c-kit proto-oncogene is involved in ACC pathogenesis.
Therefore, we sought to delineate the role of PLK-1 in the modulation of the p53 pathway in ACC.
Therefore, we would predict that inhibition of PLK-1 would not affect p53 protein levels in ACC.
MDM2, therefore, seems unlikely to be the sole p53 regulator responsible for the disruption of p53 function in ACC.
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