These studies have consistently reported that the aberrant phenotype of TAFs is maintained for some passages in culture in the absence of continuous interaction with carcinoma cells.
Although SUMO-1 has been demonstrated to be elevated in RA-SF in the absence of continuous stimulation with inflammatory cytokines and to be part of the stable activation of RA-SF, TNF-α in the inflamed synovium may enhance further the expression of SUMO-1 and, thus, contribute to the resistance of RA-SF against apoptosis.
Although direct effects of IFN on CML cells have been described as a mechanism of inducing remission, how this remission is maintained in the absence of continuous IFN treatment in patients with persistent molecular disease remains unknown.
These features are then maintained in quiescent, post-mitotic cells even in the absence of continuous β-catenin signalling and allow extremely high expression levels of this enzyme [31].
Although we have certainly noted a very rapid and impressive improvement in glycemia with this initial insulin treatment (14), we believe that in the absence of continuous intensive therapy this would not have been sustained.
We hypothesized that IFN induces a self-renewing population of leukemia-specific CTL that contribute to remission in the absence of continuous therapy.
Furthrmore, we found that tolerace lost when LTx was delayed 100days post-DST suggesting that alloantigen-primed CD4+ T-cells have extended but finite lifetimes in the absence of continuous alloantigen exposure (Fig. 1).
According to the real time position of the PAM, such results demonstrate that in the absence of continuous visual contact with a target object, memory-guided responses are mediated by a context-dependent visual percept laid down and maintained by the ventral visual pathway.
The higher amount of biofilm coverage at day 8 suggests a possible regeneration of the biofilm in the absence of continuous CAZS treatments.
In the absence of continuous sedation, or previous analgesic ordering, a medical doctor was called in case of any pain or agitation events [ 1].
