A third mechanism by which docking proteins can be negatively regulated by protein phosphorylation is via changes in their "social behaviour", specifically alterations in their ability to interact with crucial interaction partners or in their subcellular localisation (Fig. 6D; [ 4]).
In spite of proper formation of polymerase complexes, the activity of RNPs including NLS mutations in PB2 was progressively reduced, in parallel to the decrease in their ability to interact with α-importin [10], as reflected in the activity of a CAT replicon in vivo (Fig. 2D).
This paper describes the behaviour of ftsQ point mutants, created by random mutagenesis without regard to their phenotype, in which FtsQ is impaired in its ability to interact with its Escherichia coli division partners.
In order to prove their in vitro ability to interact with viral enzymes and to act as HIV inhibitors, we have studied the antiviral potentiality of highly hydrophilic and dispersible carboxylated multi-walled carbon nanotubes (ox-MWCNT) and the activity exerted by the same nanomaterial bearing antiretroviral drugs and hydrophilic functionalities.
Mutants in centromere function are often impaired in their ability to interact with microtubules and the presence of TBZ exacerbates this defect, reducing cell viability, but has only a very mild effect on wild type growth.
In contrast, the D142A mutant was impaired in its ability to interact with beta-arrestin and to undergo agonist-induced internalization.
Part of the answer may lie in the promiscuous nature of AP-1 in its ability to interact with a diverse network of factors that may lead to complex transcriptional outcomes that are dependent on higher order transcriptosome network dynamics.
Children who are severely neglected may experience cognitive delays and language deficits, disruptions in their body's stress responses, and problems in their ability to interact with authorities and peers.
