Sentence examples for in a zymogen form from inspiring English sources

Most MMPs are synthesized and secreted in a zymogen form.

Alternatively, EpCAM might be synthesized in a zymogen form (inactive precursor) [ 26], which is converted to its active form by this proteolytic action [ 12, 13].

The urokinase-plasminogen activator (uPA) is secreted in a zymogen form as inactive single-chain proenzyme (pro-uPA) by tumour and/or by stromal cells and is converted by limited proteolytic cleavage into the active two-chain enzyme.

The same happens for the regulation of muscle satellite cells, where a number of secreted growth factors are bound to the proteoglycan components of the basal lamina or to the surface of satellite cells where they can be locally sequestered in an inactive zymogen form or presented in an active signaling state [18].

Protein C circulates in the blood in zymogen form (inactivated form) at a concentration of approximately 4 μg/ml.

In its zymogen form, FVII is a single chain protein which is cleaved once between R152 and I153 upon activation to its enzyme form FVIIa, consisting of a light and a heavy chain linked by one disulfide bond.

Cleavage of plasminogen in zymogen form at an Arg-Val bond generates plasmin, an active enzyme that degrades fibrin component of thrombin [ 1].

In the case of TG3, calcium access to the related site in the zymogen form is hampered by the flexible loop (residues 462 471), which must be cleaved to allow entry.

While no structure has been solved for a propeptide in complex with an inhibited mature enzyme, it is likely that these propeptides bind to the enzymes in a conformation resembling the zymogen form (14, 25 27).

The MMPs are initially synthesized in an enzymatically inactive or zymogen form [ 9] and are activated in some conditions.

FADD, in turn, contains a death effector domain that binds to an analogous domain repeated in tandem within the zymogen form of procaspase-8, forming the so-called death-inducing signaling complex (DISC), made up of Fas/CD95, FADD and procaspase-8 [20], which drives cells to apoptosis.