Secondly, a number of genes that act in the nervous system have been shown to be refractory to RNAi in a wild type context, but efficiently inactivated in an rrf-3 RNAi hyper-sensitive background [17].
In this model, rasl11b role would already be inhibited in a wild-type context, which is consistent with our finding that rasl11b knock down has weak phenotype in wild-type embryos.
In lgl- clones induced in a wild-type context, where lgl mutant cells do not lose polarity, dmyc transcription is not altered.
DOI: http://dx.doi.org/10.7554/eLife.06541.014 > -wrap-foot> Next, we analysed zfDysGFP dynamics at the fibre tips, in a wild-type context, where it competes for binding with endogenous Dystrophin, or in dmd ta222a/ta222a mutants.
Perhaps True Grit will contain a warning of strong language "in a Wild West retribution context" and Blue Valentine will admit to strong language "in a marital breakdown context".
The location or locations of the original hybridisations is also unclear, as is whether they occurred in a wild or domesticated context.
Furthermore, azurin is pointed as a therapeutic tool for poor-prognosis breast carcinomas overexpressing P-cadherin in a wild type E-cadherin context [ 39].
Using a cross-design, we tested the effect of elevated levels of exogenous corticosterone on the physiology of pregnant females in different immune contexts in a wild population of common lizards (Lacerta vivipara).
Overexpression of βPS or TorsoDβPScyt in a wild-type background does not broaden Race or hnt expression, suggesting that whereas integrin signaling is required to augment BMP signaling, it is not limiting with respect to this function in a wild-type context.
However, in a context where even wild type RSV infections fail to induce a strong long lasting protective immunity, these recombinant RSV vaccines, which can be less immunogenic than the wild type virus because of attenuation, may not bring the final clue to the issue of RSV vaccination.
