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Studies were performed in a two-compartment left-ventricular (LV) model that allowed stimulation of global, anterior-region, or posterior-region hypokinesis in a torso chamber with heart-to-background activity similar to that in clinical studies.
Additionally, the Monte Carlo-based reconstruction enabled recovery of the true activity concentration in the myocardium of a cardiac phantom mounted in a torso phantom regardless of whether the torso was empty or water-filled.
A mathematical model of the human cardiac ventricles embedded in a torso is used to simulate the effect of multiple ion channel block on the electrical activity of the heart from ion channel to electrocardiogram.
ECG simulations have also been performed using 3D heart models embedded in a torso (Lines et al., 2003b; Chapelle et al., 2009; Potse et al., 2009; Zemzemi, 2009; Boulakia et al., 2010; Keller et al., 2011; Zemzemi et al., 2011).
The human bidomain model of the heart embedded in a torso allows for ECG simulations to be conducted with realistic representation of human anatomy and electrophysiological function, and could be used for further investigations including specific drug effects or disease conditions.
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