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Sample size determination for a binary response in a superiority clinical trial using a hybrid classical and Bayesian procedure.
Selection of the treatment effect for sample size determination in a superiority clinical trial using a hybrid classical and Bayesian procedure.
Selection of the effect size for sample size determination for a continuous response in a superiority clinical trial using a hybrid classical and Bayesian procedure.
First, the value of blinding in NI trial is under debate, especially if the endpoints are subjective.[6] In a superiority trial, a blinded investigator who has a preliminary belief in superiority of the test drug cannot manipulate the results to support his belief.
In a superiority trial, the aim is to show that a new treatment is better than standard therapy.
Use of an ITT approach as in a superiority trial sometimes increases the chance of falsely claiming equivalence [ 38, 39].
Similar(51)
Stating the smallest difference to be detected is necessary in planning a superiority trial.
Recently, Kali et al. [ 28] compared the two types of sequences in humans and in dogs suggesting a superiority of T2* for characterization of acute reperfusion myocardial hemorrhage.
One would use a non-inferiority design in one trial and a superiority design in the other trial.
Although IVCC was not worse than IAC in therapeutic effect, a superiority between them still needs to be explored.
Both armies were well-equipped, but the Nationalists had a superiority in armour and were unopposed in the air.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com