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As with other antibiotics, TMP/SMX must be given in a sufficient dose at a proper frequency to produce adequate concentrations at the site of infection for successful eradication of the pathogen.
If given in a sufficient dose, methadone prevents opiate addicts from withdrawal symptoms after cessation of heroin use [ 5].
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This leads us to the theory that every patient in the end develops SOS, if a sufficient dose of oxaliplatin is given.
In addition, a sufficient dose of flecainide has to be achieved with the potential of side effects as this drug has a relatively narrow therapeutic range.
But Finch's results suggested instead that cells and genes in aged mammals function no differently from those in younger animals, given the right physiological milieu--in this case, a sufficient dose of glucocorticoids.
To reduce the incidence of pre-eclampsia in nulliparous women, in accordance with the suggestion of a recent meta-analysis that low dose aspirin might decrease this incidence by more than half if used early enough in and at a sufficient dose during pregnancy (more than 75 mg).
Interestingly, even homologous serum could enhance MC-dependent vascular leakage in our system, where a sufficient dose of virus is injected i.p. to establish a systemic infection.
These data show that all protocols successfully detected increases in uterine weights when a sufficient dose level of the weak agonists was administered, whether the substances were known or provided as coded doses to the laboratory.
The elimination half-life of trazodone IR is relatively short (6.6 h after a single 100-mg dose), therefore, repeated daily administrations are often used in order to achieve a sufficient dose level for MDD patients, but such a dosing regimen can be inconvenient, and can lead to missed doses and reduced compliance.
56 Thus, while food fortification may offer some protection against vitamin D deficiency in children, 57 it is unlikely a sufficient dose could be delivered to achieve adequate serum levels in children with deficiency.
Therefore, it is critical to administer a sufficient dose, especially in the first days of treatment.
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