Healthy vagal function is reflected in a subtle increase in heart rate while breathing in and a subtle decrease while breathing out.
This pattern contrasts with the dysregulation seen in the DLPFC, which was characterised by decreased GR-1C and GR-1H mRNA transcripts in bipolar disorder, a subtle decrease in pan GR mRNA, and no change in GR-1B mRNA [ 41].
These results indicate that disease-causing mutations in Rab7 cause a subtle decrease in the rate of membrane exchange.
The decrease in the magnitude of the negative peak at 222 nm and differences in the CD signal suggest a subtle decrease in α-helical content in the secondary structure of the Fas DD caused by the V254N mutation.
This variant displayed 140-fold decrease in affinity for cruzipain and a subtle decrease in the affinity for papain (K i = 27 ± 1.5 pM).
However, in contrast to gene expression, a subtle decrease in total SOCS3 protein was observed after 12 weeks of MTS exposure.
Rv0557 possesses relaxed substrate specificity towards Ac1PIM1 (Schaeffer et al., 1999; Mishra et al., 2009;) and its deletion from M. tuberculosis resulted in a viable mutant with a subtle decrease in the lipomannan and lipoarabinomannan contents (Torrelles et al., 2009), indicating a superficial role of Rv0557 in the biosynthesis of PIMs, lipomannan and lipoarabinomannan.
Intriguingly, in contrast to Mel-CVR cells, CREB knockdown only led to a subtle decrease in AEBP1 mRNA levels in Mel-CV cells.
In miR-222 overexpressing cells, there was a subtle decrease in the G1 peak, accompanied by an increased cell fraction in S-G2-M phase.
Giemsa staining of mouse marrows revealed a subtle decrease in cell density in Tg and KO congenic collagen X samples, apparent as presence of more open spaces (Fig. 2A).
