Fibrosis poses a substantial setback in regenerative medicine.
"That was a substantial setback for Vitro and a substantial victory for the holdouts".
The judgment is a substantial setback for the prime minister, Theresa May, who wants to set the exit process in motion by March.
"This could represent a substantial setback to their program," David Albright, president of the Institute for Science and International Security, a private group in Washington that tracks nuclear proliferation, said of the problem behind the Bushehr upset.
While these tactics conformed to the national government's political priorities, they were a substantial setback for municipal Shanghai's global aspirations.
So when an athlete or a businessperson veers off course, it can create a substantial setback — one that could take years to recover from, if at all.
The extremist group earlier in June suffered a substantial battlefield setback when Kurdish-led fighters seized another Syrian town on the Turkish border, Tal Abyad, cutting a major supply route to Islamic State's de facto capital, Raqqa.
FORT MILL, S.C. — Republican presidential candidate Ben Carson has taken a sharp dive in recent national polls, another substantial setback for the retired neurosurgeon's campaign that comes amid ongoing scrutiny over his grasp of foreign policy issues.
Still, for all of the applause in Washington and London and the very substantial setback the loss of the city represents for the Taliban, its conquest is not a knockout blow.
Mr. Bush spoke only hours before the Florida Supreme Court ruled that the results of manual recounts in Dade, Broward and Palm Beach Counties must be included in Florida's final vote totals, a substantial legal setback for his brother.
