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Addition of heparanase to the culture medium resulted in a substantial, dose dependent decrease in ConA activation and proliferation of the spleen cells (Fig. 3A).
Exposing cultured PBMCs to either GOS or GOS/FOS fractions resulted in a substantial dose-dependent increase of tumour necrosis factor-α (TNF-α) production in LPS challenged PBMCs.
Current guidelines for fenofibrate use in Western countries recommend a substantial dose reduction (between 30 and 69%) when renal function is impaired but with significant variation in the threshold at which this should be implemented.
We co-expressed Aurora-A (1 µg) with different amounts of PUM2, and immunoblotting analysis revealed that the increase in the protein amount of Aurora-A was accompanied by a substantial dose dependent increase in the steady-state protein amount of PUM2 (Figure 3A).
As well as providing precise spatial control over cells irradiated, the pulsed nature of the ultrasoft X-ray source allows the dose of X-rays to be controlled, and as the system is capable of delivering 3 Gy s−1, a substantial dose may be given in a short time.
Through Dec. 14 This three-decade survey administers a substantial dose of Bruce Nauman's cerebrally punishing visual poetry.
Similarly, primary cultures of glial cells transduced with the Lv-shVIM vector presented a substantial, dose-dependent decrease in vimentin levels with respect to the control vector (Fig. 2C).
All antigens were formulated in QS21 adjuvant that had previously demonstrated a substantial dose-sparing ability as well as eliciting a strong immune response [15].
HuH7 cells treated with BIO showed a substantial, dose-dependent increase in TCF/LEF reporter activity.
Simulator studies have also found a substantial dose-response effect, in which raised concentrations of tetrahydrocannabinol were associated with increased crash risk.
