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In recent years, a number of PBA methods have been developed whose null hypothesis being tested can be broadly classified as 'self-contained' versus 'competitive' based on whether comparisons were made between genes in a specific pathway and non-associated genes or other genes in the genome.
The number of involved proteins in a specific pathway and corresponding p value are shown on the right side of column.
First of all, compared to whole-genome analyses, restricting analyses to SNPs in a specific pathway reduces the number of multiple tests performed in the analysis of a study population, thereby reducing the probability of false positive associations and increasing the effective power of the study.
These representative subsets of genes involved in a specific pathway may vary between studies.
Substances that were negligible or not carcinogenic in a specific pathway were excluded.
Isoforms can exist to alter the number of enzymatic reactions in a specific pathway.
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One caveat of this method is its limitation in further in-depth study of a specific pathway.
They found that cat allergen activates a specific pathway in the body, once in the presence of a common bacterial toxin.
In addition to the NF-kappa-B pathway, the JNK pathway is also a specific pathway in tumor initiation and progression, including PC [ 47, 48].
In this report, we have identified a specific pathway that mediates CIMP in KRAS-positive CRCs.
Only cell lines with the highest correlation should be used to study a specific pathway in vitro.
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