Sentence examples for in a specific orientation from inspiring English sources

The second molecule exhibits great in-plane rotational freedom and could not be modelled in a specific orientation.

As further shown for FGFR3, this processing by Cdc37 deactivates the kinase and presents it, in a specific orientation established in the complex, for direct recognition by Hsp90.

The compounds were designed to investigate whether the extra OH group in a specific orientation could establish an additional hydrogen bond with the C1 domain of PK-C, thus providing a DAG analogue with reduced lipophilicity.

Thus, it is possible that with a β-augmentation mechanism, SurA binds to only one type (e.g., odd-even) of hairpin in a specific orientation, based on the properties of the substrate, such as its connection loop and hydrophobic surface (e.g., the Ar-X-Ar motif), as well as the peptide direction.

Here we show that this is because of the requirement to present integrin α5β1 (the FN receptor) ligands in specifically oriented, polyvalent displays; by engineering controlled self-assembly of the 9th 10th type III FN domain pair (FIII9 10, the minimal integrin α5β1 ligand) immobilised in a specific orientation to cell culture surfaces.

The results lead to a new model of MATα pro-peptide signal leader, which suggests that the N and C-termini of MATα pro-peptide need to be presented in a specific orientation for proper interaction with the cellular secretion machinery and for efficient protein secretion.

It is tempting to speculate that the VNTR stabilizes the elements' RNA secondary structure in a way that ensures a specific orientation of the 5' CT/ Alu-like domain and the 3' SINE-R relative to each other.

Cellulase enzymes are not immobilized in any specific orientation, as the cellulase enzyme may approach the substrate at any orientation within a cellulase solution.

The second one consists of finding opinion words in a context specific orientation.

In fact, the A391E mutation in FGFR3 appears analogous to the V664E mutation in the Neu receptor in that both strengthen the association of the helices in a specific active orientation.

Amine-coupling was found to be the most reliable method for manufacturing repeatable and consistent TLR3 BRE sensor surfaces, although this immobilization schema is not tailored to place the receptor in a spatially-specific orientation.