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Our own investigation of V(D J recombination, using a similar strategy to that applied here, demonstrated that although the base at position -1 is apparently flipped, it does not appear to engage in a specific interaction with aromatic amino acid residues in the recombinase that would indicate capture of the flipped base (JB and RC to be presented elsewhere).
These amino acids are placed on a loop, which is suggested to take part in a specific interaction between the exfoliative toxin and desmoglein 1.
Although studies by Chambers and Horton [ 31] failed to demonstrate bone resorption by mononuclear phagocytes, other observations suggested that tumour-infiltrating macrophages [ 32], as well as polymethylmethacrylate-induced inflammatory macrophages [ 33], are capable of bone resorption in a specific interaction with stromal cells.
In light of the findings of surface charge conservation and from the mutation studies, we propose a model in which E18 in the α2-region of RF1 is not only involved in establishing the negatively charged surface patch important for interaction with the positively charged counterpart in RF3 but also involved in a specific interaction with RF3.
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We defined the Edge Weight (K E ) as the number of databases in which a specific interaction from the ensemble graph was present in each of the databases from which it was assembled.
In addition, a specific interaction between TRAP1 and GCN2 was identified, as confirmed by co-IP experiments and confocal microscopy.
In addition, a specific interaction between ETO1 and AtCUL3, a constituent of a new type of E3 ubiquitin ligase complex, suggests the molecular mechanism in promoting AtACS5 degradation by the proteasome-dependent pathway.
The data presented here suggest that each of the three domains found in UBXN7 enables a specific interaction to occur.
A GOx-avidin D conjugate (GOx-Av) is used to selectively immobilize the enzyme and the subsequent polymerization events in wells expressing a specific interaction between biotin and GOx-Av (Fig. 1).
Structural studies provide evidence for a specific interaction in which incoming dimers interact with the nucleotides of the terminal dimers at the plus end and trigger their hydrolysis 17.
In summary, we identified a specific interaction between PHD1KDM5B and the unmodified H3K4 peptide.
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