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We just don't know how many of these vehicles outside of these groups will do in a small overlap test," Mr. Lund said.
It is noteworthy that the sequence comparison of the two sets only resulted in a small overlap, specifically, 5 of the 176 new sRNAs.
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Schuhmacher et al. [ 5], in particular, used a B cell line carrying a conditional, tetracycline-regulated myc gene, and found that myc induction resulted in only a small overlap in regulated mRNAs at 4 hours post-induction when comparing polyA mRNA and NRO RNA on microarrays.
Nevertheless, the reliability of the results of these studies is thought to be relatively poor because in general quite a small overlap between datasets of experimentally identified interactions is observed.
We also compared the actions of GH and T3 in liver and found a small overlap comprising genes involved in lipogenesis suggesting the common regulation of SREBP transcription factors.
Even at the peak of rod degeneration at P21, when apoptotic TUNEL+ rods and microglia-engulfed rods were both highly prevalent in the ONL, only a small overlap was found between these two populations (Fig 3J).
Since these three datasets were collected in different times, CASIA-IrisV3-Interval and CASIA-IrisV3-Lamp have a small overlap in subjects.
A large overlap in the distribution of [F]FMISO and C-2-deoxyglucose and a small overlap in the distribution of [F]FMISO and C-methionine were observed [ 12].
In searching for the genes over-represented in gut microbiomes, we identified 237 gene families commonly enriched in adult-type and 136 families in infant-type microbiomes, with a small overlap.
The expression patterns of the genes VBP1 and CUL2 exhibited a small overlap in both assays and revealed no elevated expression levels in the primary tumour samples.
To conclude, our study showed that although prognostic signatures may have been developed using a different approach, different platforms and statistical tools on different sets of comparable patients, with a small overlap in gene identity as a consequence, they can result in similar predictions of outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com