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Across the 100 cases the average decline in output per person from the pre-crisis level is 11.3% and recovery takes an average of 8.4 years, resulting in a severity score of 19.7 (see chart).
We can combine the effect in a severity given by Open image in new window Fig. 2 Viscosity as function of (a) process temperature (b) severity S = Ttau^{a} (1 with temperature T (°C) and reaction time (tau) (hours).
No evidences have demonstrated the occurance in a severity manner.
Only substantial – and not statistical – arguments that favour an increased weight of disease activity (clinical status) in a severity index could do that.
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This speculation is supported by our data showing strong correlations between the severity of ER stress and the ratio of Ser473/Thr308, and the phosphorylation profile of several AKT substrates in a severity-dependent manner (Fig. S1), but not with phosphorylation level of Ser473 alone (Fig. 1D).
Furthermore, we observed that metabolic acidosis was associated with ICU mortality in a severity-dependent manner and was also associated with refractory shock.
In this study, we further demonstrate that ER stress modulates AKT downstream substrates specificity in a severity-dependent manner.
To conclude, our data demonstrate that ER stress modulates AKT target substrate specificity in a severity-dependent manner.
A recent publication from Zhang et al. demonstrated that ER stress promotes GRP78 localization on the cell surface in a severity-dependent manner [4].
Here, we demonstrate that ER stress modulates AKT substrate specificity in a severity-dependent manner, as shown by phospho-specific antibodies against known AKT targets.
Here, our results not only demonstrated ER stress induced phosphorylation of Ser473, it altered AKT substrate recognition profile in a severity-dependent manner.
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