Sentence examples for in a setting of profound from inspiring English sources

Higher doses could also be considered in a setting of profound lymphocytopenia.

Aren't you in the same territory as Michael Gove? A: I think I'm not in the same territory because I have a set of profound concerns with Michael Gove's approach to this.

At stake is a set of profound questions, as political as they are existential.

The absence of response from the professional sleep medicine community to the abuse of propofol as a sleep aid in the setting of profound insomnia is puzzling to me but possibly intentional.

Glyburide has been shown to continue to stimulate insulin secretion in the setting of profound hypoglycemia to a greater extent when compared with glimepiride (20), in part because glyburide accumulates within the β-cell (21), unlike other sulfonylureas, prolonging insulin secretion.

The finding of a high level of glucagon insulin colocalization in the setting of profound β-cell ablation argues against β-cell dedifferentiation occurring following alloxan plus caerulein.

Invasive pulmonary aspergillosis (IPA) is a major cause of morbidity and mortality in patients with hematological malignancies in the setting of profound neutropenia and/or hematopoietic stem cell transplantation.

Not all exposed vessels carry the same risk of recurrent bleeding, and sometimes endoscopic therapy may not be warranted in the setting of profound acid inhibition therapy.

About half of severe bleeding episodes (54.7 %) occurred in the setting of profound thrombocytopenia with platelet counts below 20 × 109/L.

In the setting of profound, symptomatic and acute hyponatremia, failure to timely correct, at least in part, hyponatremia places the patient at risk of hyponatremic encephalopathy, seizure and brain herniation whereas an overly rapid increase in plasma sodium concentration renders patient vulnerable to the much dreaded osmotic demyelination syndrome (OD) [7].

This tragic chain of events occurs if adaptive responses are overwhelmed and the "regulatory volume decrease" (as detailed below) mechanism fails to quell the increase in brain cell volume, such as in the setting of profound and abrupt decrease of PNa levels.