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Similar adaptive mitochondrial responses were identified in a serial study of Zucker diabetic fatty rats where the animals initially upregulated their oxidative capacity in the face of progressive insulin resistance (27).
A second major finding of our study is the strong relationship between the evolution of cardiac conduction disturbances on resting ECG and the increase in the HV interval in a serial study.
In a serial study in rats recovering from transient cerebral ischemia performed by Lin et al., an initial decrease in vascular density (based on the Q value) and an increase in vessel size (based on VSI) was observed in the reperfused cortex at day 1 and 3 [ 52].
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In detail, each participant was assigned a serial study ID.
In a separate serial study (N = 4 saline, N = 4 treated) MRI was performed on the 3rd day of treatment, the time of treatment effect, and the tumor-inoculated rat brain was snap-frozen in liquid isopentane chilled on dry ice, and the brain was overlaid with Tissue-Tek embedding matrix (O.C.T. compound, Sakura Finetek U.S.A, Inc., Torrance, CA) and stored at -80°C.
Braakman et al. demonstrated the dynamics of amyloid plaque formation and development in a serial MRI study in a transgenic mouse model [24].
For example, in a serial slaughter study [ 13] it was observed that peak expression of IGF1 in MFP and estrogen receptor-α (ESR1) in PAR from 100 kg body weight Holstein heifers coincided with peak mammary epithelial cell proliferation [ 14].
In a serial EEG study of 151 patients with SAH, the authors found that even on day 1, certain patterns predicted later vasospasm, including the presence of very brief frontally predominant biphasic delta waves ('axial bursts'), focal polymorphic delta overlying an area of clot, or a predominance of unreactive delta frequency slowing.
The standardized uptake value (SUV) can be used to aid determination of the significance of areas FDG uptake and provides a method of quantification in serial studies.
Increasingly, oncologic radiologists are expected to provide objective assessment of change in masses, on serial studies, in order to validate response or resistance to new chemotherapeutic agents.
In the 31 infants in whom serial studies were completed, expected age-related changes were demonstrated between the 3- and 24-month examinations.
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