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Enhancing ER should hence be realized in a sequential treatment design, in which a continuation phase treatment with a specific focus on ER directly follows, once patients sufficiently responded to treatment.
Opinion of rheumatologists were used to determine the maximal number of drugs in a sequential treatment strategy.
Combining induction and concomitant chemotherapy with radiation, that is, in a sequential treatment approach, has the potential for improving disease outcomes.
Combination treatments with sensitizer drugs (24 h) followed by TRAIL (24 h) were carried out in a sequential treatment format to identify candidates that sensitized PC3-TR cells to TRAIL-induced apoptosis.
In addition, new treatments in oncology offer particular methodological problems for cost-effectiveness analyses as (i) new agents often add a new element in a sequential treatment pathway and (ii) the standard comparator is either absent or highly variable across treatment centres and national healthcare systems.
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In the present study, a sequential treatment process was carried out using a fungal sp. (Phanerochaete sp).
M-VAC showed encouraging efficacy and reversible toxicities in patients who had progressed after GC chemotherapy and, especially, M-VAC appears to be a reasonable option as a sequential treatment regimen in patients who responded previously to GC chemotherapy.
35 In another study, a triple combination cream consisting of fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% was used in an alternating sequential treatment pattern, cycling with a series of GA peels, for the treatment of moderate to severe melasma.
Other sequential combinations of oral vinorelbine with paclitaxel or docetaxel or epirubicin are being explored, suggesting a possible role for the oral formulation in a sequential prolonged treatment in MBC.
In all sequential treatments (Groups 7, 8, 10), the second drug application was performed 3 minutes after the first one.
We performed frequency tests to assess whether switch to one of the antibiotics generally led to a significant increase in inhibition in the sequential treatment protocols.
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