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This study suggests that 4OGOMV, a natural occurring potent immunosuppressant in a selected dose, could prove clinically useful in preventing and treating SAH-induced vasospasm and early brain injury.
Likewise, in the observation of NeuN, GFAP and BrdU polyclonal immunostating, our result supports 4OGOMV, in a selected dose, is able to reduce pro-inflammatory cytokines in the early stage of SAH-induced vascular deformity and also attenuate SAH induced cerebral apoptosis.
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All substances were prepared in corn oil based on repository instructions, with the exception of laboratory 2, which used methyl cellulose; the dose volumes to be administered were calculated based on daily body weights in order to maintain selected doses.
The variation in selected doses reflects the history of investigation of this therapy outside the hemophilia setting, in which there was often uncertainty regarding the dose required for optimal hemostatic efficacy, tempered by early concerns that this treatment could have thrombogenic potential.
Baseline and post-ASA measures included aggregation, slope, and lag time in response to selected doses of 4 known platelet agonists, and urinary excretion of the thromboxane B2 metabolite 11- dehydrothromboxane B2 (Tx-M).
In a selected few genes, α-particle doses of 1.0 Gy at a dose rate of ~1 Gy/hr were able to elicit the same fold induction as a 10 Gy X-ray dose at ~ 1 Gy/min.
Our study highlights the importance of carefully considering the oral dose used in animal experiments and provides useful information in selecting doses for future studies.
Pharmacokinetic studies were performed to select dose regimens that result in serum concentrations similar to those found in humans [ 6, 22].
Subsequent studies are needed to further titrate the doses to test whether the in vitro-derived FIC indices can serve as a guide to select doses in vivo in order to maximize the benefit of synergy while minimizing the risk of adverse events.
Dose responses of each compound were determined in order to select doses without effect alone.
Chemical genetics provides tools for controlling the activity of a selected enzyme in a dose-dependent and reversible manner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com