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And in a secondary case that somehow involves both diamonds and surfboards, Mickey is equally good at guessing what either of these very different items is worth During the hiatus he took between "The Lincoln Lawyer" and this book, Mickey spent time recovering from both a bullet in his gut and an addiction to painkillers.
The estimation procedure depends on 3 assumptions: 1) ascertainment of patients whose symptoms appear before day T is complete, 2) transmission events are independent, and 3) the generation interval, the time from symptom onset in a primary case to symptom onset in a secondary case, has a known frequency distribution.
For symptomatic close contacts infected with pandemic (H1N1) 2009, the median of generation time (i.e., the time from illness onset in an index case to illness onset in a secondary case) were 2.4 days; it was shorter for flight passenger contacts than nonpassenger contacts (1.6 days vs. 2.5 days) (Table 1).
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§Generation time is time from illness onset in an index case-patient to illness onset in a secondary case-patient.
The probability of observing additional cases was derived by using the serial interval; that is, the time from illness onset in the primary case-patient to illness onset in a secondary case-patient, and the transmissibility of MERS (Technical Appendix).
To compare with results (9 ), we also assume the duration of infectiousness T to be 8.4 days, as estimated from the time from onset of symptoms in the index patient to onset of symptoms in a secondary case-patient in Singapore (12 ) and obtain R 0 = exp[ rT] = 3.41.
Participating sites recorded the nature of the relationship between the index case and each contact, the setting in which the two persons interacted, and the direction of transmission (i.e., whether the contact was identified as the source case in relation to the index case, a secondary case in relation to the index case, or whether the direction of transmission remained unidentified).
Standard epidemiologic investigations usually require a history of exposure to a known primary case of disease in order to link a secondary case to the outbreak.
The generation time is the time lag between infection in a primary case and a secondary case.
A candidate explanation for this finding is that it reflects reverse causality; index cases who had a secondary case in their household were more likely to receive oseltamivir, perhaps because they were more likely to seek treatment.
The most recent count, according to the California Department of Health as of Monday afternoon, is 26 cases, which includes 22 confirmed cases in California (one of which is a secondary case who had direct contact with a case from Disneyland), two in Utah, one in Colorado and one in Washington, though more will almost certainly be reported in the coming days and weeks.
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