The GSEA showed significant enrichment in a range of pathways related to unsaturated (LC-PUFA) fatty acid biosynthesis (ko01040), fatty acid elongation (ko00062), steroid biosynthesis (ko00100), N-glycan biosynthesis (ko00510 and ko00513), terpenoid backbone biosynthesis (ko00900), proteasome (ko03050), protein export (ko03060) and protein processing (ko04141) (Fig. 1).
As shown in Figure 1, the metabolic fluxes showed observable shifts between a range of pathways in the central carbon metabolic network upon PQ exposure, including the following.
The prognostic value of PTEN gene status has been suggested using an mRNA microarray signature for a range of pathways in 281 patients (Markert et al, 2011) where a cluster exhibiting a stem cell like signature and also P53 and PTEN loss had a very poor outcome.
The genes in our list are involved in a wide range of pathways and processes related to GM, from DNA repair to cell cycle regulation and cell death.
In the field of foregut and lung development, as in many other fields, work on signalling molecules and transcription factors in a wide range of pathways is gradually building up a picture of key events in morphogenesis of the foregut, lung and other organ systems [6,33,44].
A drastic chemical effect is observed in both the brain metabolic profile and in a remarkable range of pathways.
MiRNAs are recognized as critical links in cellular pathways and carcinogenesis, regulating expression of genes in a wide range of pathways critical for cancer development and progression.
SLC16 family members are involved in a wide range of pathways including energy metabolism, and are involved in the transport of lactic acid, pyruvate and ketones across the plasma membrane.
Group B is present in all the fungi and its members appear to function in a wide range of pathways from the control of protein activity, transcription, translation and the cell cycle, to the vesicular transport of proteins and the control of fungal virulence.
A functional role of TSPO and the entire multimeric protein complex has been implicated in a range of cellular biochemical pathways, such as cholesterol transport and steroidogenesis, membrane biogenesis, immunomodulation and oxidative processes [3].
