The benefit of 1-day testing on screening acceptability is evident, but the impact on sensitivity should be evaluated in a screening situation with a proper study design and a larger sample size.
Resistance to ivermectin in the equine roundworm is suspected in Norway, but a proper study on this has not been conducted yet.
However, before mipomersen can be used as concomitant therapy in apheresis-treated patients, a proper study must be performed in this patient group.
For an evaluation of varicose veins, the patient will need to be in an upright position to enable a proper study of blood flow direction Unlike arterial ultrasonography, venous ultrasonography is carried out with the probe in a transversal position, (perpendicular to the vein axis).
Whether women have to wait longer for a second transplantation cannot be answered in this study, and should be addressed in a proper designed study with sufficient numbers of patients.
In a proper epidemiological study, guns themselves would be treated as a risk factor for many types of violence or injury—just as mosquitoes would be treated as a risk factor for contracting malaria, for example.
Thus, in order to ensure proper study power, median ages were used as cut-off points.
Execution of a rigorous external validation study rests in proper study design, application of suitable statistical methods, and transparent reporting.
No, there is no evidence that bad decisions "invariably go in big teams' favour" (although a proper statistical study would be interesting).
Though the results are preliminary (the treatment must still be tested in a proper double-blind study, in which neither patients nor physicians know who is getting the drug rather than the placebo), the work has attracted great interest.
An understanding of comparative anatomy, histology, and physiology of the normal liver and gallbladder between humans and rodents will aid investigators in proper study design and meaningful interpretation of experimental outcomes.
