We believe that approaches similar to those outlined here can prove useful in treating complex genetic diseases by helping identify optimal combinations of up/down regulation of genes (or optimal combinations of single target drugs) that have minimal side effects and are most effective in moving the equilibrium of the network in its entirety to a preferred state.
In this phase behavior can be most easily adapted to obtain or preserve a preferred state [ 30, 31] or to choose an alternative coping strategy.
Celibacy is a preferred state, and Pauline theology subordinates the matrimonial state of human existence to a life of chastity".
States 27 and 39 are also equilibria in this conflict, but only according to SMR and GMR stability, which means sanctioning DMs can move to less preferred states when blocking the given DM's unilateral improvement, which is a movement by a DM to a more preferred state.
This is important because women who are unemployed are not observed to be in their most preferred state, and must be classified appropriately in a choice model.
Both computation and experiment suggest that in LeuT these binding events trigger a series of local perturbations that are propagated from one end of the transporter to the other, generating significant changes in the preferred state [29], [34].
In order to keep the brain in this preferred state, β-END apparently allows the animal to perform feeding and drinking activities (see below) as well as social grooming [ 76], which relieve stress and may restore a disturbed balance.
Because 43 is Nash equilibrium, no DM can unilaterally move to a more preferred state from state 43.
On longer distances, this simple argument will have to be modified due to compensatory mutations resulting in gradual shift of the preferred state at some positions; nonetheless, it indicates a dramatic slowing down of divergence at a scale of the HIV-1-SIVcpz divergence.
These results indicate that whatever the reason (dimerization, even residual dimerization as in MAD2R133A, could certainly promote conversion or at least stabilize the closed state), C-MAD2 is the preferred state in solution even in the absence of binding partners.
