Further, this photoactivatable ligand has the property of being an antagonist in the caged state and an agonist in the uncaged state, enabling a precise window for kinetic perturbation in single cells.
Without a precise "window of opportunity", spike generation depends on synaptic summation.
Proteins, enzymes, fats, hormones and other compounds have to be absorbed, broken down, metabolised and produced in a precise time window to allow important processes such as growth, reproduction, metabolism, and cellular repair.
The progressive loss of WT1 in both ganglion and chromaffin cells, suggests its potential repressor role of differentiation in a precise temporal window during the development of the human PSNS and GENS.
It is becoming increasingly clear that TFs can be classified as a function of their age and that in some cases they acquired their regulatory role in a precise time window of the evolutionary process.
This raises the possibility to predict RA development in high-risk populations and may further allow a more precise "window of opportunity" for early and effective treatment interventions.
The Peak Day method identifies a much more precise window of the periconceptional period than that used in most previous studies of periconceptional exposures.
The engineered Fc-nonbinding (crystallizable fragment-nonbinding) CD3 antibody has lower mitogenicity and a precise therapeutic window for disease remission in patients with type 1 diabetes.
The precise window of time in which intestinal Hnf4α was altered differs in our study, as compared to what had been previously reported [10].
This suggests that genistein is acting during a precise developmental window around 12 hpf.
