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Our data in a poor risk population is promising and warrants further investigation.
However, the CR rate of 60% in a poor risk group is encouraging, and merits further investigation in a larger Phase II trial.
The patients transplanted in first CR all has a Scotland and Newcastle Lymphoma Group SNLGG) Prognostic Index (Proctor et al., 1991) which indicated they were in a poor risk prognostic group.
The treatment results observed after sequential adriamycin followed by CMF in a poor risk subset could probably be explained by an increased density of the anthracycline, which was delivered at full dose within the first 9 weeks of treatment.
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Although significant, CRP values at discharge would represent only a poor risk factor in the prediction of adverse outcome, with an area under the ROC curve of 0.58.
A: Poor at-risk communities in urban areas tend to be the most vulnerable.
This form of intensification therapy with marrow rescue has been shown to be effective and of low toxicity and now forms part of a randomised controlled trial in poor risk Hodgkin's patients as identified by the SNLG index (Proctor et al., 1992).
There was no significant difference in histone acetylation in patients with poor risk cytogenetics versus other cytogenetic groups.
Temsirolimus was investigated in untreated poor risk disease.
The response data would suggest that this combination should not be further investigated in this poor risk population.
Median survival in the favorable risk group was 30 months, in the intermediate risk group 14 months, and in the poor risk group 5 months.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com