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In addition the calibrated parameters (Table 1) are all in a plausible range.
Two high outliers [ 15, 16] were eliminated resulting in a plausible range of 5-25%, with a mean of 18% and median of 21%.
Across CS− and CS+, estimated response amplitudes are in a plausible range, and responses to the US are higher than responses to the CS.
We further conduct a model sensitivity analysis by varying the shape parameter α in a plausible range from 2 to 5 to see the effect of the shape parameter on incidence and survival summary statistics.
Estimated response latencies to the US are consistent with those reported previously (Bach et al., 2010a), and the number of SF in the inter-trial interval are equally in a plausible range (Bach et al., in press).
This estimate seems to be in a plausible range based on the studies that were included in the current study, and would suggest that approximately 0.25 % (or 1 in 400 hospitalized patients) of all patients who are not hospitalized due to an ADR will die as a result of an ADR during their stay in a European hospital.
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We set Dirac delta priors on one parameter at a time, keeping all other priors as above and varying the single parameter in question over a plausible range, as might be done operationally when no accurate data are available.
Conversely, there was no need to evoke undetected cases in WA in order to estimate a plausible range of values for R.
24 The average annual cost of INR monitoring for warfarin patients was based on an analysis undertaken by NICE 25 in the base case, with a plausible range tested in sensitivity analysis due to regional variation within the UK.
Variations in human diets across a plausible range of intakes have been shown to have no effect on blood pH.
The two indirect measurements of incidence in this analysis fell within a plausible range of HIV incidence in both countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com