Here, we provide direct evidence for this model in a physiological context.
However, the following experiments will provide evidence suggesting that the R1746Q mutation of CEP290 may generate a deleterious phenotype in a physiological context.
These results are interpreted in a physiological context of general reduction in the metabolism of metamorphic larvae.
Notably, we showed that Wnt inhibition is not an artefact of the ectopic expression of the miRNA, as it also occurred in a physiological context (e.g., in primary cells, in vivo, loss-of-function).
In a physiological context, variable regulatory effects of NF-κB on different promoters offer the potential for target genes to be under the transcriptional control of distinct NF-κB subunits.
Thus, understanding how nucleation responds to the presence of oxygen is the key to understanding how sickling proceeds in a physiological context.
In light of available experimental and structural data, our data confirm that the first binding mode represents Sbi-IV interaction with C3d (and C3) in a physiological context.
To further test the role of Notch signalling in a physiological context, 32D or FDCP-mix cells were cultured on fibroblast layers that expressed or did not express the Notch ligand Jagged1.
Functional genomic and metabolomics data is becoming easier to obtain and process, however interpreting the significance of these data in a physiological context is challenging since the metabolic framework of all microalgae remains poorly understood.
To assess the role of PDE4D in β1AR function in a more physiological context, changes in the heart rate of mice in response to β-adrenergic stimulation were measured, as it is established that in vivo contraction rate is primarily controlled by β1AR (Rohrer et al, 1996, 1999; Devic et al, 2001).
As seen in Figure 3a, Caskin1 immunoprecipitates both Nck and EphB1.To prove in a more physiological context that a specific phosphotyrosine residue in EphB1 may recruit the complex of Nck/Caskin1, we used phosphopeptides immobilized on beads to precipitate proteins, as described earlier [ 20, 21].
