During the conduct of this trial, investigators in a parallel Phase I trial of SU5416 on the same schedule at The University of California, Los Angeles, USA reported DLT (projectile vomiting and severe headache) at 190 mg m−2 (Rosen et al, 1999).
A parallel Phase I study of the ADVAX vaccine alone was conducted separately, as reported in the accompanying manuscript.
A parallel phase I study investigated the use of anti-PD-L1 in a similar patient cohort (Brahmer et al, 2012).
In this study, as in the parallel phase I study of DMXAA (Jameson et al, submitted), only a single unconfirmed tumour response was seen.
The R1 is in series with a parallel arrangement of the constant phase element (CPE - denoted as Q in the equivalent circuit) and the R2-W elements.
In parallel, phase-locked images of OH* chemiluminescence are collected and analyzed in order to determine the associated flame dynamics.
Our in vitro studies on HT-29 cells showed that PRI-2191 – the more active analog – used along with 5-FU caused accumulation of cells in the G0/G1 cell cycle phase with a parallel decreasing of cells in the S stage.
The Americans are proposing a phased withdrawal of Israeli troops from part of the West Bank in a parallel effort to specific Palestinian moves to improve their fight against terrorism and their security cooperation with Israel.
As a further confirmation, we found that exposure of SVZ NPCs to Th1 but not Th2 cytokines lead to significant increase (33 46%) of cells in the G0/ G1 phase (P ≤ 0.005) and to a parallel decrease of cells in the S phase (P ≤ 0.005), when compared with controls.
The parallel phase in the history of the French Empire-Commonwealth ended when four generals at the head of the purely mercenary Foreign Legion seized Algiers as a preliminary to seizing all of France.
In a parallel study, we measured the levels of systemic markers of inflammation in acute phase and remission of FMF [56].
