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Dr. Linehan practices dialectical behavior therapy, the only therapy that has been demonstrated to be effective in a number of randomized clinical trials.
The antidepressant efficacy of milnacipran has been clearly established in a number of randomized, double-blind, placebo-controlled clinical trials, and it has been widely used for treating major depressive disorder.
In a number of randomized trials in infectious/inflammatory conditions such as ventilator-associated pneumonia and acute respiratory distress syndrome, conducted over the past years, statins failed to improve outcome [25 27].
The predictive value of HER2 for chemotherapy sensitivity was explored retrospectively in a number of randomized trials in the adjuvant and metastatic settings.
Efficacy and tolerability of atomoxetine in children and adolescents have been demonstrated in a number of randomized, placebo-controlled trials (for an overview and meta-analysis, see [ 22].
Atomoxetine is a selective norepinephrine reuptake inhibitor, and its efficacy and tolerability were demonstrated in a number of randomized, placebo-controlled trials among children and adolescents [ 14- 17].
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Regarding the effectiveness of efforts to promote physical activity in RA, a number of randomized controlled trials have been published [ 8, 9].
Chemo-resistance is a key characteristic of acute myeloid leukaemia (AML) in older patients and a number of randomized trials have now been completed to assess this approach.
Recently, a number of randomized trials in nursing homes and in community-living elderly found hip protectors ineffective (Cameron et al 2002, 2003; Van Schorr et al 2003; Birks et al 2004).
The efficacy of becaplermin gel in the management of neuropathic ulcers has been documented by a number of randomized controlled trials, reviewed in more detail elsewhere (Papanas and Maltezos 2007).
Third-generation aromatase inhibitors (AI) recently became available for the treatment of breast cancer, and a number of randomized trials in postmenopausal women with advanced breast cancer have shown the superiority of AI over standard endocrine agents such as tamoxifen and megestrol acetate [ 24- 26].
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