Together with data that unexposed TLR4−/− mice have a normal survival ability in SPF conditions; these data indicate that TLR4 was not required for BMC homeostasis.
While mice deficient in both isoforms of Stat3 are embryonic lethal at day 6.5 to 7 [24] and mice deficient in Stat3α die within 24 hr of birth, mice deficient in Stat3β have normal survival and fertility [6].
Whereas mice with Vhl deletion in endocrine pancreas showed normal survival, mice lacking pVHL in pancreatic progenitor cells that give arise to both exocrine and endocrine pancreas (Pdx1-Cre;Vhl f/f), exhibited significant postnatal death.
WT-GFP knock-in mice were fertile and showed normal survival but tended to be smaller than WT littermates (Fig. 1D and E).
In yeast, autophagy is required for normal survival as well as lifespan extension by rapamycin (Alvers et al., 2009a, 2009b).
It has been demonstrated that encapsulated erythrocites present normal morphology, normal metabolic and antigenic properties, and normal survival in vivo [ 16].
NLRP3-/ and P2X7-/ did not display an increased susceptibility to disseminated candidiasis, as shown by normal survival and fungal loads in the organs.
This uniformity is also seen in a number of secondary measures of neurodevelopmental outcome in particular the rate of "normal" survival, where the point estimates for risk ratio were almost identical across the trials (although only significant in one study).
Thus, we hypothesised, based on recent breast cancer literature, that the ACCENT data would have substantive differences in survival estimates with log-normal survival modelling, rather than with the Cox model (Royston, 2001; Chapman et al, 2008).
The results showed that genetic depletion of p53 results in a completely normal development and survival of G2 tert−/− embryos (Fig. 6D).
