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At a given temperature, increasing pressure resulted in a modest decrease in the rate of NO removal, with little effect on the amount of NO2 and N2O formed.
Specifically for a 3-level Cartesian grid, a Cartesian-based movement technique including particle indexing is demonstrated to result in a modest decrease in overall simulation expense of 34% compared with a ray-tracing technique combined with stored cell-connectivity.
Increasing test temperature resulted in a modest decrease in endurance limit by about 12% from 20 to 150 °C, while a significant decrease in endurance limit by about 23% was observed from 150 to 250 °C at high number of cycles.
However, in cells pretreated with Compound A prior to doxorubicin stimulation, we discovered that NF-κB inhibition had no effect on basal expression of cIAP1, although combination treatment did result in a modest decrease in cIAP1 mRNA (Figure 2A).
Similarly, since reduced Ubqn levels result in a modest decrease in APP levels, whereas expression of both human wildtype and the AD variant of UBQLN1 leads to adult onset, age-dependent eye degeneration in Drosophila [47], UBQLN1 may also be considered as a possible drug target for AD.
Exposure of cells to 8 μM BITC for 3 h resulted in a modest decrease in levels of Mcl-1.
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However, without improved characterization of the model parameters and model inputs, the reduction in the observational uncertainty will result in only a modest decrease in the range of the source mass flux that is not ruled out in history matching.
Trp in α1 of PecS is important for folding, as evidenced by its substitution causing protein aggregation, but substitution of Asp results in only a modest decrease in DNA-binding affinity, in contrast to the ∼140-fold decrease observed for MftR-D56S.
In fact, a modest decrease in copying fidelity was observed.
If the variants studied here result in only a modest decrease in IRGM levels, then the relative effect may be insufficient to influence disease risk in Japanese individuals, who show significantly higher expression than Europeans.
The effect of the D108N mutation is even more drastic, resulting in a 150-fold decrease in kcat and a modest decrease (4-fold) in KM, consistent with a significant role of this residue in catalysis.
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