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If sequence coverage is low, it is better to obtain population estimators in a larger window to avoid incorrect estimates caused by stochastic error.
DIST imputes the statistics at the unmeasured SNPs in a prediction window as a function of (i) the statistics at measured SNPs in a larger window, henceforth denoted as extended window, and (ii) the correlation matrix of both measured and unmeasured statistics, as estimated from a relevant reference dataset.
Dyad positioning scores [ 25] were obtained by counting the number of nucleosome dyads that sit within a fixed narrow window (± 5 bp) around a particular base pair, and dividing this by the number of dyads in a larger window (± 150 bp).
The Pearson Coefficient between replicates is improved in all cases, ranging from 0.75 to 0.94, when P score was used (Additional file 4), on which the peak call was based, indicating some sporadic noise was removed by considering the signal level of neighboring probes in a larger window.
The positioning score for a given vector base pair was calculated by counting the number of dyads in a narrow window (± 5 bp) around a particular base pair, and dividing by the number of dyads in a larger window (± 150 bp) around the same base pair.
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Furthermore, using a larger window in the computation of the mass function decreases the noise effect.
In summary, our simulations suggested that a larger window size (16−36 cM) decreases the chance of detecting false peaks.
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I chose an infant, whose body then appeared in a large window that created the illusion that the figure had depth as well as height and width.
Examples by dozens of lesser-known practitioners are featured in a large window display of mail art sent to the San Francisco artist and archivist John Held Jr.
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