However, very few studies have focused on regulatory interactions in a large-scale combination of motifs.
As most studies used multi component linkage interventions, this resulted in a large number of combinations, which made it difficult to meaningfully interpret which combinations were the most effective.
Intriguingly, 30 sets of primers in a large number of combinations failed to amplify overlapping segments of the large Pkd1l2 cDNA from several tissues including the liver, kidney and muscle; therefore, a complete sequence scan for this particular cDNA was not achieved.
Even within these broad classifications, a number of drugs, techniques and routes of administration may be used alone or together in a large number of potential combinations.
The high density of PTMs in histones and other signaling molecules results in a large number of potential combinations of marks that regulate chromatin-templated recognition processes.
That means these regions should be rich in specific types of sequences that are highly polymorphic and organized in a large number of possible combinations.
Findings of this study are interesting; if validated in a larger cohort, a combination of clinical findings, brain imaging and biomarkers could aid in early prognostication in patients with TBI.
Put butter, oil or combination in a large skillet over medium heat; when butter melts or oil is hot, cook carrot, onion, potato and thyme with a healthy sprinkling of salt and pepper.
A large Phase III trial is currently evaluating this combination in a large number of breast cancer patients.
Satraplatin (JM-216), an oral platinum compound, is currently being evaluated in a large international trial (SPARC), in combination with prednisolone as second-line treatment after docetaxel.
