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Addition of bevacizumab at a dose of 5 mg/kg to chemotherapy (5-fluorouracil plus leucovorin) resulted in a higher objective response rate (40% versus 17%), longer time to disease progression (9.0 versus 5.2 months), and longer median survival time (21.5 versus 13.8 months).
Although docetaxel resulted in a higher objective RR in this pretreated population with visceral disease, there was no statistically significant difference in median TTP or OS.
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Patients in this pilot study showed a higher objective response rate before surgery and no increased complication rate after surgery.
Several markers of the IGF-IR pathway such as nuclear insulin receptor substrate-1 were overexpressed in the transitional subset and a higher objective response rate to the combination of chemotherapy and the anti-IGF-IR antibody figitumumab was observed in patients with transitional tumours (Gualberto et al, 2010).
The three categories were: (1) A higher objective burden in Chinese cohort versus a higher subjective burden in Australian cohort, 2) Unmet need for caregiver support in Australia and China, and 3) Expectations for improving dementia services in Australia and for developing dementia services in China and are explained in more detail below.
Among the included studies, four of them reported a higher objective response in the TS -/low expression arm compared with the TS +/high expression arm [ 6, 17, 18, 31].
Findings from the qualitative and quantitative strands were presented as three categories: A higher objective burden in the Chinese cohort versus a higher subjective burden in the Australian cohort; Unmet need for caregiver support in Australia and China; and Expectations for improving dementia services in Australia and for developing dementia services in China.
However, the rising demand for care in the acute setting and the shift from secondary to primary out of hours care also results in a high objective and subjective workload for GPs.
The results clearly demonstrate that CPT-11 with gemcitabine resulted in a significantly higher objective response rate and improved quality of life compared with CPT-11, but failed to demonstrate any survival, duration of response and TTP advantage.
In a randomised multicentre trial comparing docetaxel/cisplatin and docetaxel/gemcitabine as front-line chemotherapy in NSCLC patients, a significantly higher objective response rate was achieved with docetaxel/gemcitabine in adenocarcinoma than in nonadenocarcinoma patients (Georgoulias et al, 2001).
Not surprisingly, women with a known BRCA1 or BRCA2 mutation in the family had a significantly higher objective risk, than women without a known BRCA1 or BRCA2 mutation running in the family (P=0.0001).
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