It might be expected that the prevalence of candidal infection should be higher in those with a greater severity of illness.
Increased use of hospital services by the more disadvantaged in our population reflect their greater health need and, in many cases, also a greater severity of illness [ 23, 29].
This is presumably because patients in these settings had a greater severity of illness and are likely to have more multiple co-existing conditions than patients in other parts of the hospital.
Thus, it is likely that the increased levels of pro-inflammatory cytokines are, at least in part, due to persistent epithelial damage because of impaired anti-inflammatory M2 macrophage skewing in chemerin-treated mice, as a greater severity of epithelial damage was observed in chemerin-treated mice following DSS exposure.
MacBeth and Gumley have shown in their review of premorbid adjustment and early symptom development that premorbid problems in psychosocial functioning are associated with a greater severity of illness course and, in particular, more negative symptoms [ 17].
Consistent with the exacerbated clinical signs, chemerin-treated mice showed a greater severity in histological damage as evidenced by a widely disrupted tissue architecture, the disappearance of intestinal crypts and goblet cells, marked mucosal hypertrophy and edema compared to control mice following DSS exposure.
However, patients who were uninsured on some visits were reported to have higher primary care, emergency department, and inpatient costs than patients in any other insurance category, suggesting a greater severity of illness among these patients.
This approach could have masked a greater severity of illness in the patients undergoing PAC placement.
These differences point to a greater severity of illness in patients treated with low-dose corticosteroids.
