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Any receptor agonist that does not induce a full functional response in a given functional assay of receptor activation.
N.D. indicates that genes were not detected in a given functional category.
The enrichment coefficient can be estimated as: (3) ENR = CG / L / TG / T Where: ENR – enrichment coefficient, CG – the number of genes with detected expression changes in a given functional category in the experimental gene list L, L – the number of genes in the experimental gene list, TG – total number of genes in a given functional category, T – the total number of genes assessed.
Finally, we used a network structure comparison Mantel test [ 21] to detect CT-PPI modules by their structural consistency between CT and PPI sub-networks in a given functional module.
To overcome this problem, the variable threshold method considers multiple masking schemes for the same set of variants in a given functional unit or genomic region on the basis of MAF [ 20].
The setting "Hypergeometric test" was chosen to calculate the probability of observing an equal or greater number of genes in a given functional category than in the test set.
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To study the ribosome occupancy profile in the neighbourhood of a given functional feature we start by aligning all the instances of that feature in the proteome at their starting residues (Fig. 6).
In a classical approach, the number of genes assigned to a given functional category in this set is compared with the number of genes assigned to that category in the entire genome, and deviations are evaluated according to a statistical test.
The main motivation for this kind of investigations follows from the pretty natural concept to pose the stability problem for a given functional equation in the settings of an ordered structure as an alternative for the topological or metric ones.
To avoid this problem, we may identify a particular coding region in nucleotide sequences that corresponds to a given functional domain of an enzyme such as lipase.
The hypergeometric distribution was used to assess the statistical significance of enrichment of a given functional group in the target list relative to the genome as a whole [ 125, 126].
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