Sentence examples for in a given dose from inspiring English sources

All patients in a given dose level were evaluated for at least 28 days before patients could be treated at the next higher dose level.

However, these findings suggest that the acquisition of TKI resistance accompanies the transcriptional activation of diverse transmembrane transporter molecules, altering the drug efflux/influx and cellular susceptibility in a given dose of drugs.

10, 11 Variability in response to a given dose of GH likely reflects differences in the severity of GH deficiency (GHD) and the patient's sensitivity to treatment.

However, there was up to a 10-fold variation in AUC for a given dose.

In diabetes where eNOS activity is impaired, there is less NO to be released in response to a given dose of acetylcholine [ 1, 6].

Although it has been in clinical use for over 50 years, warfarin therapy is still challenging due to a narrow therapeutic range and considerable variability in response to a given dose.

A more robust understanding of these events and mechanisms provides the necessary foundation for characterizing and quantifying sources of variability (genetic, behavioral, life stage, etc). in response to a given dose.

In addition, the plasma levels of pioglitazone were shown previously to be lower in male rats than in female rats for a given dose [ 45].

The interindividual susceptibility and variability in adrenal suppression at a given dose of ICS must be taken in consideration and explained to the patients.

In the conventional dose range, a fourfold inter-patient variability has been reported both in the systemic exposure for a given dose and in the dose required to achieve a specific target level [ 7].

A range of up to 10-fold in AUC was seen for a given dose.