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The SNPs identified in this study may serve as potential candidate loci for breast cancer risk in a further replication study in Stage III from Alberta population or independent validation in Caucasian cohorts elsewhere.
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This experiment began with a further replication of Experiments 1 3, in order to increase the power of the combined analyses (Experiment 4.1).
Confirmation of the data presented here will be sought in further replication studies in independent populations as well as studies in different breeds.
As the two SNPs appear to be common only in Asian people, further replication study is warranted in the other Asian populations as well as the Japanese.
Our positive results must be viewed as tentative and in need of further replication; because of the large number of tests performed and analyzed, it is possible that our positive results are due to chance since none of the differences were significant at Bonferroni corrected significance levels.
This lack of association requires confirmation in further replication studies.
Following our analysis of the Stage 1 follow-up, we choose a smaller subset of SNPs for further replication in an independent data set.
However, the findings are limited by the small number of patients involved and require further replication in a much larger study.
Decreased susceptibility to Gram-negative bacteria observed in the GG genotype patients in the derivation cohort did not replicate; this needs further replication tests in larger cohorts.
This result should be considered in terms of the study design, and further replication is necessary in an independent sample.
Based on meta-analysis results across arcOGEN and these in-silico replication datasets (supplementary results, available online only), we prioritised 36 SNP for de-novo replication in a further set of 6188 osteoarthritis cases and 8280 controls of European descent and for in-silico replication in 213 cases and 2531 controls from Estonia (supplementary table 1, available online only).
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