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At the earliest recorded activation sites, there was an isoelectric window in the immediate postshock period lasting 42 +/- 15 msec after which activation fronts either spread away from a site in all directions in a focal pattern (12 episodes) or else spread away in only one direction (eight episodes).
Occasionally a few basal keratinocytes showed mild immunostain in a focal pattern.
Within 2 hrs, the fluorescently-tagged protein bound to the surface of CD172a+ cells in a focal pattern (Fig. 3A); however, rESAT-6 CFP-10-FITC labeling did not overESAT-6 CFP-10-FITC labeling (Fig. 3B), indicating that the fusion prESAT-6 CFP-10-FITCelabelingact with Cdid2a directly.
The indirect immunofluorescence technique demonstrated that human alpha fetoprotein (AFP) was present in a focal pattern in the cytoplasm of malignant liver cells of patients whose sera contained AFP.
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Limitations: T2w-STIR images usually allow reliable visual identification of oedema in patients with a focal pattern of myocardial involvement, although the limited contrast-to-noise ratio (CNR) may impede the detection of subtle tissue changes in a significant minority of patients.
But residual signal alterations of the bone marrow have been also reported after the end of therapy, particularly in patients with a focal pattern before treatment (Fig. 6) [ 60].
Thyroid uptake is incidentally identified on 18F-FDG PET imaging with a frequency of almost 4%, with a diffuse uptake pattern in roughly half of cases and a focal pattern in the remainder [22].
Of 28 cases positive for 6C1, the distribution of positively stained cells showed a diffuse pattern in 67.9% (19 cases) and a focal pattern in 32.1% (9 cases).
As shown in Fig. 5, positive nuclei were labelled with a focal pattern typical of DNA replication.
Two patterns of staining were observed, a focal pattern and a more diffuse staining.
One caveat to take into account, however, is that differentiation is likely to be much more difficult in patients with advanced disease since regions that were previously unaffected may start to 'catch up' to the regions that showed a greater degree of atrophy early in the disease, resulting in a less focal pattern of loss.
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