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Loss of RB resulted in a dramatic evolution of gene expression as a result of alterations in epigenetic programming.
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With their bold use of primary colors and new level of formal complexity and compositional density, the "Models" intaglios marked a dramatic evolution in Mr. Winters's approach.
The last 10 years have witnessed a dramatic evolution in our understanding of renal cell carcinoma (RCC) biology, which has led to the development of novel medical therapies and revolutionized the approach to their clinical management.
Kid A (2000) and Amnesiac (2001) marked a dramatic evolution in Radiohead's musical style, as they incorporated experimental electronic music, krautrock and jazz influences.
After the significant improvements obtained from the mid 1970s to the mid 1990s, the past decade has seen a dramatic evolution in technology leading to new machines and new techniques for renal and multiple organ support.
"Some have worked here for 30 years who would never have imagined such a dramatic evolution of the situation," Rocco Palombella, the secretary of Uilm, a metalworkers' union, said in a statement.
The obvious expansion of its genomic size indicates that higher plant mitochondria experienced a dramatic evolution.
That lunch was a milestone in the dramatic evolution of a behind-the-scenes fund-raising network whose goal is to legalize same-sex marriage from coast to coast.
"In terms of relationships, there's been a pretty dramatic evolution recently with our outreach and success" in wooing the "trusted vendors" to Big Hollywood rather than just the studios, says Jonathan Usher, a Microsoft digital media director.
Furthermore, RB loss in the presence of therapy-induced damage can result in dramatic evolution of cells that can have significant impact on tumorigenesis not observed through loss of tumor suppressors alone.
By contrast to our failures in federal climate protection, the dramatic evolution that is transforming the forestry sector has gone almost unnoticed by the media and public.
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