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The intervention group received 250 μg IB combined with 2.5 mg albuterol by jet nebulization in a dosing schedule determined by the ACA phase.
Even if UHPLC showed better precision and sensitivity, UHPSFC method is able to give accurate results in a dosing range larger than the 80 120% range required by the European Medicines Agency.
Using typical examples, the approach proved to have great capacity to identify influential outliers from the statistical perspective, which deserves special attention in a dosing regimen.
The master mixture was administered undiluted in a dosing volume of 2 mL/kg bw to achieve the highest mixture dose of 130.1 mg/kg/day.
Over the course of the experiment, mice weighed on average about 42 g, resulting in a dosing rate per unit body weight of approximately 0.20 mg/kg/day.
The amount of omalizumab to administer, and whether to dose every 2 or every 4 weeks, is based on patient body weight and IgE level set out in a dosing table (Appendix A1).
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This finally resulted in a dose map.
The activity was measured in a dose calibrator.
nano-TiO2 exposure, in a dose-dependent manner.
The changes were in a dose-dependent manner.
MEIL displayed anti-inflammatory activity in a dose dependent manner.
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