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dTcf precipitated both Mad and Arm when the Arm amount was relatively low (Fig. 5F, lanes 2 and 3), while increasing amounts of Arm blocked the binding of dTcf and Mad in a dose-sensitive manner (Fig. 5F, lane 4).
The interaction of FOXL2 with PIAS1, UBC9 and/or SUMO-1 might thus lead to stabilization of the 50 KDa FOXL2 polypeptide in a dose-sensitive manner (Fig. 2A, B).
Given the frequency of chromosome NDJ observed in a dose-sensitive manner in bubR1 D1326N trans-heterozygotes, we decided to perform a genetic screen to identify third-chromosome haploinsufficient synthetic modifiers of the NDJ phenotype.
Region 66C3−66D4 contains matrimony (mtrm ), a gene previously reported to encode a negative regulator of Polo kinase that controls the timing of meiotic maturation and chromosome segregation in a dose-sensitive manner.
The gene dosage hypothesis predicts that genes in networks or that function in a dose-sensitive manner should be retained, because their products are required for stoichiometric balance (Freeling and Thomas 2006; Birchler and Veitia 2007; Lou et al. 2012).
It is well known for its role in gene silencing and modifies position effect variegation in a dose-sensitive manner (position effect variegation (PEV); the process of gene silencing through the spread of heterochromatin, usually detected in rearranged chromosomes or transgene insertions).
The families have extreme reactions and have to be treated in a most sensitive manner".
Already the local community can see the benefit of managing land in an ecologically sensitive manner.
It continued: "Allegations of sexual assault are treated in a timely and sensitive manner.
Because of this, it is important that we respond in a sensitive manner.
Interviews will all be conducted in a sensitive manner.
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