NMR analysis of the solution structure of the c-terminal LIM domain of two of these proteins, CRP1 (Perez-Alvarado et al, 1994) and CRP2 (Konrat et al, 1997; Weiskirchen et al, 1997; Wadman et al, 1994), has shown that two zinc-fingers constitute a LIM domain, which represent two separated structural entities held together in a distinct configuration by hydrophobic interactions (Dawid et al, 1998).
In (B – E ), each cartoon denotes a distinct configuration of Notch pathway components, with the resulting signaling state indicated schematically below.
Nonetheless, I don't think that an alternative model can really be ruled out in which the SM protein recognizes a distinct configuration of Sec17 molecules achieved only when they are bound to the 'cognate' SNARE complex.
The protease protection, NEM accessibility, and BMH crosslinking data together reveal a distinct configuration of late-stage RNCs (>96-mer) assembled in the absence vs presence of CT8.
Each adult Wunderpus photogenicus examined (n = 15) exhibited a distinct configuration of white markings on the dorsal mantle (examples illustrated in Figure 2).
Each shift in viewpoint discovers a distinct formal configuration and image.
Starting from the issue of what is the correct form for a Legendre transformation of the strain energy in terms of Eulerian and two-point tensor variables we introduce a new two-point deformation tensor, namely H=(F−F−T /2, as a possible deformation measure involving points in two distinct configurations.
One can imagine the matrices in figures 2 and 3 represent the average correlations between a single place cell's activity when the maze was in two distinct configurations indicated as bin 1 and bin2, but this is not clearly communicated.
The last 10 years have been marked by a rapid evolution in the laboratory of genetically encoded calcium sensors both figuratively and literally, resulting in 11 distinct configurations of fluorescent proteins and their attendant calcium sensor modules.
Sugar molecules, and molecules with chiral centres and double bonds, may also exist in distinct configurations.
However, the clinical significance of this distinct configuration in the DM1-expanded allele requires further analysis.
