In ROCS, a different alignment algorithm accounting shape/physicochemical properties for the query molecule orientation gives a complementary filter for the hitlist from pharmacophore-based screening.
It should be noted that the alignments obtained in our study by direct comparison of the mouse M180 and L. catta sequences differ from previous reports in which using a different alignment algorithm and software, the amelogenin sequences of 25 mammals were aligned [18], [22] (See Supporting Information).
This result is comparable with that obtained in turkey, using a different alignment algorithm [ 37], confirming the possibility to obtain satisfactory results from alignment of heterologous sequences on a reference genome assembly.
The roadway between Packwood and Cayuse Pass, added to the state highway system on a different alignment in 1905, was finally completed in 1940, and the White Pass Highway was dedicated on August 12 , 1951 opening a shortcut between southwest Washington and Yakima.
Damon can envision a different alignment in 2010, possibly with players like Alex Rodriguez, Jorge Posada and Derek Jeter as well as Damon rotating through the D.H. role.
NY 345 was assigned as part of the 1930 renumbering of state highways in New York; however, it originally followed a different alignment south of the hamlet of Madrid.
We examine this tradeoff and find that, because of a loss of information in the early steps of the approach, the alignments generated by the most common multiple sequence alignment programs are inherently unstable, and simply reversing the order of the sequences in the input file will cause a different alignment to be generated.
Some studies have suggested that the main role of the conserved Tyr is to stabilize the cluster through these aromatic and H-bond interactions and not to have any profound effect on the reduction potential; however, because the Tyr in different proteins tends to take a different alignment, this hypothesis cannot be generalized to all HiPIPs.
Since knee alignment have great impact on biomechanical force transmission which may influence the degree of extrusion, a larger sample allowing enough numbers in different alignment categories would be valuable in future work [ 34].
Both of the latter two cases had multiple best hits but resulted in different alignment choices probably due to insert size statistics, in turn due to the particular input read batch.
